Prophyrins Question And Answers

Hemoglobin And Prophyrins

Question 1. Jaundice
Answer:

• The yellow pigmentation of the skin, mucous membrane & deeper tissues due to increased bilirubin levels in the blood is called jaundice
• It occurs when the bilirubin level exceeds 2 mg%

Jaundice Types:

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Question 2. Hemoglobin – structure & synthesis.
Answer:

Hemoglobin Structure:

• Hemoglobin is a conjugated protein
• It consists of the protein- globin & iron-containing pigment called heme

1. Globin

• It contains four polypeptide chains, two alpha & two beta chains
• The alpha chain contains 141 amino acids, while the beta chain contains 146 amino acids

2. Heme

• It is a porphyrin derivative known as Protoporphyrin IX with iron at its center

Hemoglobin Synthesis:

• During Kreb’s cycle, the acetic acid is converted into succinyl CoA
• Two molecules of succinyl CoA combine with two molecules of glycine to form pyrrole compound
• Four pyrroles combine to form protoporphyrin
• Protoporphyrin IX is involved in Heme formation along with iron
• Each heme combines with one globin to form hemoglobin