Chelating Agents Question And Answers

Chelating Agents

 

Write Drug Treatment Of BAL.
Or
Write A Short Note On BAL.
Or
Write A Short Note On British Anti­Lewisite.
Answer:

The term BAL refers to British until-Lewisite or Dimercaprol.

• BAL is an oily pungent, smelling, viscous liquid developed during World War I by British as an antidote to arsenical war gas lewisite.
• Two SH groups of dimercaprol bind those metals which produce their toxicity by interacting with sulfhydryl-containing enzymes in the body, i.e. arsenic, mercury, gold, bismuth, nickel, and copper.

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British Anti­Lewisite Uses

• It is used in poisoning by arsenic, mercury, gold, bismuth, nickel, and copper.
• It is used as an adjuvant to calcium disodium edetate in lead poisoning.
• It is used as an adjuvant to penicillamine in copper poisoning and Wilson’s disease.

British Anti­Lewisite Contraindications

It is contraindicated in iron and cadmium poisoning because the dimercaprol-Fe and dimercaprol-Cd complex is itself toxic.

British Anti­Lewisite Adverse Effects

Rise in BP, tachycardia, vomiting, tingling, burning sensations, inflammation of the mucous membrane, sweating, cramps, headache, and anxiety.