Anticancer Drugs
Question 1. Write A Short Note On The Toxicity Of Methotrexate.
Answer:
Methotrexate is a folate antagonist.
- The toxicity of methotrexate is caused due to overdosages.
- Aspirin and sulphonamides increase the toxicity of methotrexate by decreasing its renal tubular excretion.
- Folinic acid rapidly reverses the toxicity of methotrexate. The folinic acid gets converted to a form of tetrahydrofolate which is utilized by the cells.
- Thymidine also counteracts methotrexate toxicity.
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