What Causes Eosinophilia and How Is It Diagnosed?

Eosinophilia

Question 1. Write a short note on eosinophilia.
Answer:

“Understanding eosinophilia: Causes and diagnosis”

Eosinophils: They are granular white blood cells.

They have coarse, deep red staining granules in the cytoplasm and have usually two nuclear lobes.

Eosinophils are involved in reactions to foreign proteins and to antigen-antibody reactions.
An increase in the number of eosinophilic leucocytes above 400/ml is referred to as eosinophilia.

Why do malignant tumors grow faster

“Treatment options for eosinophilia in hematology”

Eosinophilia

The causes are:

Allergic disorders: Bronchial asthma, urticaria, drug hypersensitivity
Parasitic infestations: Trichinosis, Echinococcosis, Intestinal parasitism
Skin disease: Pemphigus, dermatitis, herpetiformis, erythemamultiforme
Loeffler syndrome
Tropical eosinophilia
Pulmonary infiltration with eosinophilia syndrome.
Haemophiliac disease: Chronic myeloid leukemia, pernicious anemia, Hogdkin’s disease, polycythemia vera
Malignant disease
Irradiation
Miscellaneous disorders: Sarcoidosis, Rheumatoid arthritis, Polyarthritis nodosa.

“Importance of diagnosing eosinophilia early”

Question 2. Write the difference between agglutination and precipitation reaction.
Answer:

“Case studies on eosinophilia outcomes”

Agglutination

A type of antigen-antibody reaction in which a solid antigen clumps together with a soluble antibody.
Agglutination means the collection of separate particles into clumps.
Blood typing is done based on agglutination.

Fast growing malignant tumors

“Radiographic features of eosinophilia-related complications”

Precipitation

In this the soluble antigens like tetanus toxins are converted into insoluble forms and then precipitated.
In the precipitation test precipitate forms in a solution containing a soluble antigen upon the addition of serum containing the specific precipitin.
The reaction is specific.
This is used for the identification of unknown proteins, determination of type of blood stains, types of pneumococci and meningococci.