Verrucous Carcinoma

Verrucous Carcinoma

Verrucous carcinoma is a diffused papillary, nonmetastasizing well-differentiated malignant neoplasm of oral epithelium.

Verrucous Carcinoma  is also known as Ackerman’s tumor.

Verrucous Carcinoma Clinical Features

• Tumor occurs during 60 years of life and males are more commonly affcted.
• Common locations for verrucous carcinoma are gingiva,alveolar mucosa and buccal mucosa.
• Verrucous carcinoma presents as slow growing, exophytic,papillary growth having white pebbly surface.

“Role Of Hpv In Causing Verrucous Carcinoma”

• Carcinoma occurs either as single entity or there can be multiple lesions involving diffrent parts of oral cavity.
• Lesions on buccal mucosa are sometimes very extensive and often cause pain, tenderness and diffilty in taking the food.
• Regional lymph nodes are often enlarged and tender.

“Early Signs Of Verrucous Carcinoma In Skin Or Mucosa”

Verrucous Carcinoma Histopathology

• Hyperplastic epithelium often exhibits a papillary surface being covered by the thick layer of parakeratin.
• Massively enlarged bulb like acanthotic rete ridges are seen which invaginated into underlying connective tissue stroma.
• Many deep cleft like spaces lined by thick layer of parakeratin, these extend from the surface of epithelium and project deep into the center of bulbous rete ridges. This is known as parakeratin plugging.

“Understanding The Role Of Hpv In Causing Verrucous Carcinoma”

• All bulbous rete ridges of the epithelium projects into the connective tissue and is known as pushing margin.
• The basement membrane is intact and underlying connective tissue shows inflammatory cell infitration.
• Formation of epithelial pearls and microcytes are seen.

“The Role Of Biopsy In Diagnosing Verrucous Carcinoma Accurately”

 Verrucous Carcinoma Treatment

• Surgical excision or laser therapy is done.
• Prognosis should be good.