Verrucous Carcinoma

Verrucous carcinoma is a diffused papillary, nonmetastasizing well-differentiated malignant neoplasm of oral epithelium.

Verrucous Carcinoma is also known as Ackerman’s tumor.

Verrucous Carcinoma Clinical Features

Tumor occurs during 60 years of life and males are more commonly affcted.
Common locations for verrucous carcinoma are gingiva,alveolar mucosa and buccal mucosa.
Verrucous carcinoma presents as slow growing, exophytic,papillary growth having white pebbly surface.
Carcinoma occurs either as single entity or there can be multiple lesions involving diffrent parts of oral cavity.
Lesions on buccal mucosa are sometimes very extensive and often cause pain, tenderness and diffilty in taking the food.
Regional lymph nodes are often enlarged and tender.

Hyperplastic epithelium often exhibits a papillary surface being covered by the thick layer of parakeratin.
Massively enlarged bulb like acanthotic rete ridges are seen which invaginated into underlying connective tissue stroma.
Many deep cleft like spaces lined by thick layer of parakeratin, these extend from the surface of epithelium and project deep into the center of bulbous rete ridges. This is known as parakeratin plugging.
All bulbous rete ridges of the epithelium projects into the connective tissue and is known as pushing margin.
The basement membrane is intact and underlying connective tissue shows inflammatory cell infitration.
Formation of epithelial pearls and microcytes are seen.

Benign and malignant tumors of Oral cavity Verrucous carcinoma