Treatment For Hodgkin Lymphoma
Describe the causes of generalized lymphadenopathy and management of Hodgkin’s lymphoma.
Answer. Enlargement of lymph gland is called as lymphadenopathy.
“Role Of Precision Medicine In Hodgkin Lymphoma“
Hodgkin Lymphoma Treatment
Causes of Generalized Lymphadenopathy
- Acute infection process: Glandular fever.
- Tuberculosis
- Syphilis: In secondary stage
- Disseminated lupus erythematosus
- Blood disease: Acute lymphatic leukemia, chronic lymphatic leukaemia
- Neoplasm: Secondary carcinoma
- HIV infection and AIDS
- Sarcoidosis.
“Standard Treatment Options For Hodgkin Lymphoma”
Management of Hodgkin’s Lymphoma Stage I and II:
- Mainly radiotherapy, i.e. external high cobalt radiotherapy
- Above the diaphragm: Y-fild therapy, covering cervical,axillary, mediastinal lymph nodes.
- Below the diaphragm: Mantle or inverted-Y fild therapy covering para-aortic and iliac nodes.
- Chemotherapy is also given.
Hodgkin’s Disease Treatment Options
“Role Of Radiation Therapy In Hodgkin Lymphoma”
Brentuximab Vedotin For Hodgkin Lymphoma
Management of Hodgkin’s Lymphoma Stage III and IV:
- In this, mainly chemotherapy is given.
- Regimens used are:
MoPP regimen
- Mechlorethamine: 6 mg/sqm on 1st and 8th day
- Oncovine: 1.4 mg/sqm on 1st and 10th day
- Procarbazine: 100 mg orally daily for 10 days
- Prednisolone: 45 mg orally daily for 10 days
“Chemotherapy For Hodgkin Lymphoma Explained”
MOPP combination is given in 6 courses with no drugs given from 15th to 28th day.
Radiation Therapy For Hodgkin Lymphoma
“Targeted Therapy For Hodgkin Lymphoma“
ABVd Regimen
- Adriamycin: 30 mg/sqm
- Bleomycin: 10 mg/sqm
- Vinblastine: 6 mg/sqm
- Dacarbazine: 350 mg/sqm
The cycle is repeated on 20th day.
Splenectomy is done in many patients except with stage IV disease.
Leave a Reply