Therapeutic Uses Of Amoxicillin

Therapeutic Uses Of Amoxicillin

Question 1. Describe The Pharmacological Action And Uses Of Amoxicillin. Why Is It Combined With Clavulinic Acid?
Or
Write About The Therapeutic Uses Of Amoxicillin.
Answer:

Amoxicillin Pharmacological Action

Uses Of Amoxicillin

• It is used to treat Lyme disease.
• It is used to treat urinary tract infections caused by E coli, streptococci, etc.
• It is used to treat typhoid, sub-acute bacterial endocarditis, and gonorrhea.
• It is the most frequently used antibiotic for the treatment of dental infections.
• It is the first choice drug for prophylaxis of local wound infection as well as distant infection following dental surgery in susceptible patients.

Combination Of Amoxicillin And Clavulanic Acid

Amoxicillin is susceptible to degradation by β-lactamase pro- reducing bacteria, which are resistant to a broad spectrum of β-lactam antibiotics, such as penicillin.

Clavulanic acid is a β lactamase inhibitor, so after binding to β lactamase clavulanic acid gets inactivated and is known as a suicide inhibitor. So to prevent the destruction of amoxicillin by β lactamase enzyme amoxicillin is combined with clavulanic acid.

Question 2. Explain The Basis Of Use For The Combination Of Amoxicillin And Clavulanic Acid.
Or
Write A Short Note On Amoxicillin + Clavulanic Acid.
Or
Justify Combination Of Amoxicillin And Clavulanic Acid.
Or
Explain Why It Is Rational To Give Amoxicillin With Clavulanic Acid.
Answer:

Amoxicillin is susceptible to degradation by β-lactamase producing bacteria, which are resistant to a broad spectrum of β-lactam antibiotics, such as penicillin.

Clavulanic acid is a β lactamase inhibitor, so after binding to β lactamase clavulanic acid gets inactivated and is known as a suicide inhibitor.

So to prevent the destruction of amoxicillin by β lactamase enzyme amoxicillin is combined with clavulanic acid. Its route of administration is oral, IM, or IV