Subantimicrobial Dose Of Doxycycline

Subantimicrobial Dose Of Doxycycline

Subantimicrobial-Dose doxycycline (SDD) is a 20-mg dose of doxycycline (Periostat) that is approved and indicated as an adjunct to scaling and root planning in the treatment of chronic periodontitis.

• Subantimicrobial-Dose doxycycline (SDD) is taken twice daily for 3 months, up to a maximum of 9 months of continuous dosing.
• The 20 mg dose exerts its therapeutic effect by enzyme, cytokine and osteoclast inhibition rather than by any antibiotic effect.
• Subantimicrobial dose doxycycline may help to prevent the destruction of periodontal attachment by controlling the activation of matrix metalloproteinases, primary collagenase and gelatins, from both infiltrating cells and resident cells of periodontium, primary neutrophils.
• Subantimicrobial dose doxycycline consisting of doxycycline cyclate 20 mg two times a day provide significant additional benefit to scaling and root planning in the treatment of periodontitis. At this dosage benefits obtained are derived from anti-collagenase and antiinflammatory property of doxycyline.
• Research studies have found no detectable antimicrobial effect on the oral flora or the bacterial flora and other regions of the body and have identified clinical benefit when used as an adjunct to scaling and root planning.
• At present, SDD is the only host modulation therapy specifically indicated for the treatment of chronic periodontitis.