Phenytoin
Give An Account Of Adverse Reaction Of Phenytoin.
Answer:
1. Phenytoin leads to dose-dependent toxicity which leads to the following side effects:
Phenytoin Toxicity
- Hyperplasia and hypertrophy of gums.
- Hypersensitivity reaction, i.e. urticaria, rashes, and lymphadenopathy.
- Hirsutism, acne, and coarsening of facial features.
- Hyperglycemia can occur due to decreased secretion of insulin.
- Hypocalcemia occurs due to decreased absorption of calcium from the gut.
- Megaloblastic anemia can occur due to folate deficiency.
- Osteomalacia occurs due to an increase in the metabolism of vitamin D.
- Fetal hydantoin syndrome occurs when used in pregnancy.
Phenytoin: Uses, Mechanism of Action, and Side Effects
2. In high concentration phenytoin can lead to:
- CNS: On chronic therapy, vestibulocerebella syndrome can occur.
- CVS: On IV administration it may cause hypotension and cardiac arrhythmias
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