Histopathology Of Intraepithelial Carcinom

This is also called as carcinoma in situ

Intraepithelial carcinoma is a condition which arises frequently on skin, but occurs also on mucus membrane including those of oral cavity.
Metastasis is impossible in intra epithelial carcinoma.
Bowen’s disease is a special form of intraepithelial carcinoma occurring with some frequency on skin, particularly in patients who have had arsenic
therapy and is often associated with development of internal or extra cutaneous cancer.

Histopathology Of Intraepithelial Carcinom Histological Features

Keratin may or may not be found on the surface of lesion but, if present, is more apt to be parakeratin rather than orthokeratin.

Benign and malignant tumors of Oral cavity Intraepithelial carcinoma

In some instances, there appears to be hyperplasia of the altered epithelium while in others there is atrophy.
An increased nuclear/cytoplasmic ratio and nuclear hyperchromatism is seen.
Cellular pleomorphism is common
There is loss of orientation of cells and loss of their normal polarity.
Sometimes a sharp line of division between normal or altered epithelium extends from surface down to the connective tissue rather then a blending of epithelial changes.