Ewing’s Sarcoma

 Ewing’s Sarcoma

Ewing’s sarcoma is a small round cell tumor. It arises inside the bone.

 Ewing’s Sarcoma Clinical Features

• It occurs predominantly in children and young adults between 5 to 25 years with median age of 13 years.
• It is more common in males as compared to females.
• Whites develop this tumor more commonly but in blacks not even single case is reported.
• Pain in Ewing’s sarcoma is intermittnt in nature.
• Swelling of the bone is earliest clinical sign.
• Long bones of extremities are more commonly affcted besides these skull, clavicle, ribs, shoulder are also affcted.

ewing’s sarcoma

“Risk Factors For Developing Ewing’S Sarcoma”

• Ewing’s sarcoma in occur more commonly in mandible as compared to maxilla
• Paresthesia and loosening of teeth are common fidings in Ewing’s sarcoma of jaw.
• Appearance of jaw swelling is rapid and intra­oral mass become ulcerated.
• Tumor commonly penetrates the cortex resulting in soft tissue mass which overlie affected area of bone.

Ewing’s Sarcoma Radiographic Features

• Most common fiding is formation of layers of new subperiosteal bone which produces onion skin appearance of fim.
• There is presence of irregular lytic bone destruction with ill-defied margins.

“Early Signs Of Ewing’S Sarcoma In Children And Teens”

 Ewing’s Sarcoma Histopathology

• Ewing’s sarcoma is highly cellular which consists of solid sheets or mass of small round cells with litte stroma, few connective tissue septa can also be seen.
• Cells are small and round in shape having scanty cytoplasm. Nuclei of cell is large round to oval in shape with dispersed chromatin and hyperchromasia.
• Borders of cell are indistinct.
• Cells are arranged in filigree pattern.

ewing sarcoma treatment

“Role Of Genetics In Causing Ewing’S Sarcoma”

• Mitotic figures are commonly seen.
• Multiple small vascular channels are also present.
• Hemorrhage with vascular lakes or sinuses can be seen.
• There is also presence of geographic necrosis with perivascular sparing.
• Necrosis can be seen on the opposite side of fragment of bone.

 Ewing’s Sarcoma Histological Differential Diagnosis

• Small cell osteosarcoma
• Peripheral neuroectodermal tumor of infancy
• Metastatic neuroblastoma
• Mesenchymal chondrosarcoma
• Malignant lymphoma
• Embryonal rhabdomyosarcoma.

“Understanding The Role Of Genetics In Ewing’S Sarcoma”

 Ewing’s Sarcoma Treatment

• Radical surgical excision should be done alone or coupled with X­ray radiation.
• Current treatment consists of combined surgery, radiotherapy and multidrug chemotherapy which led to 40 to 80% of survival rates.