Dentinogenesis
- Dentinogenesis is a two-phase sequence of dentin formation
- Collagen is formed and calcified
- The next layer of prevention is formed
- Dentinogenesis is not a continuous process, period of rest and accentuation is denoted by incremental lines
- Dentinogenesis becomes at the cusp tips after the odontoblasts have differentiated
Dentinogenesis Steps:
- Differentiation of odontoblast due to the involvement of fibronectin, decorin, laminin, and chondroitin sulfate
- TGF, IGF & BMP are released from inner enamel epithelium
- Taken up by pre odontoblast
- The shape of the odontoblast changes from ovoid to a columnar shape
- Length of odontoblast increases upto 40pm
- Proline is released into the extracellular collagenous matrix of the prevention
- Proteins get involved in mineralization
- Alkaline phosphatase present in matrix vesicles increases the concentration of phosphates
- This combines with calcium and forms apatite crystals
- As a result of matrix formation in this way, the odontoblast process lengthens Thus prevention is formed
- Each increment of prevention is formed and gets calcified than the next increment of presenting forms the Rate of dentin formation
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