Competitive And Noncompetitive Inhibition

Competitive And Noncompetitive Inhibition

Question 1. Competitive & noncompetitive inhibition
Answer:

“Competitive vs Noncompetitive Inhibition”

“Noncompetitive Enzyme Inhibitors”

Question 2. Name five clinically important enzymes in plasma. Indicate their normal values & clinical significance (or) Enzymes of diagnostic importance
Answer:

“Competitive Inhibition Mechanisms”

Question 3. SGOT & SGPT (or) Clinically important transaminases
Answer:

• SGOT- Serum glutamate pyruvate transaminase & SGPT- Serum glutamate oxaloacetate transaminase are important transaminases
• SGOT is found in cytosol & mitochondria while SGPT is a cytosol enzyme

“Noncompetitive Inhibition in Enzymes”

Question 4. Serum alkaline phosphatase (or) Enzyme inhibition
Answer:

• It is derived from bone & liver

Serum alkaline phosphatase Normal value:

Serum alkaline phosphatase in Adults

• 1.5-5 units (Bodansky)
• 10 units ( King-Armstrong)

“Competitive and Noncompetitive Inhibitors”

Serum alkaline phosphatase in Children

• 5-14 units Bodansky
• 15-20 units King Armstrong Increased In:

Serum alkaline phosphatase Rickets

• Hyperparathyroidism
• Bone disorders
• Obstructive jaundice Isoenzymes:
• Alpha 1- ALP
• Alpha 2- heat labile ALP

“Enzyme Inhibition by Competitive Inhibitors”

• Alpha 2- heat-stable ALP H Pre beta ALP
• Gamma ALP Importance of isoenzymes:
• Alpha 2- heat labile ALP increases in hepatitis
• Pre-beta ALP indicates bone diseases