Chemotherapy of Pulmonary Tuberculosis: First-Line and MDR/XDR-TB Treatment

Chemotherapy of Pulmonary Tuberculosis: First-Line and MDR/XDR-TB Treatment

Question. Write a short note on the chemotherapy of pulmonary tuberculosis.

Answer.

Chemotherapy of pulmonary tuberculosis.

Drugs for primary chemotherapy (First-line anti-tubercular drugs)

“Understanding pulmonary TB chemotherapy through FAQs: First-line vs MDR/XDR-TB treatment explained”

Under dots following treatment regimen is used

“Importance of studying TB chemotherapy for healthcare professionals: Questions explained”

Second-line antituberculous drugs

“Common challenges in managing MDR-TB and XDR-TB effectively: FAQs provided”

Treatment regimen under rntcP for Mdr-tB (Multidrug-resistant tB) and Xdr—tB (extensively drugresistant tB)

1. For MDR-TB:

1. Six drugs in intensive phase for 6-9 months: Kanamycin,
2. Levoflxacin, Ethionamide, Cycloserine, Pyrazinamide and Ethambutol.
3. Four drugs in continuation phase for 18 months:
   Levofloxacin, Ethionamide, Cycloserine and
   Ethambutol.
4. Reserve drug is p­aminosalicylic acid.

Chemotherapy of Pulmonary Tuberculosis: First-Line and MDR/XDR-TB Treatment

“Factors influencing success with TB chemotherapy knowledge: Q&A”

2. For XDR-TB

1. Seven drugs in intensive phase for 6-12 months:
   Capreomycin, p-aminosalicylic acid, Moxiflxacin,high­dose Isoniazid, Clofazimine, Linezolid,
   Amoxicillin and Clavulinic acid.
2. Six drugs in continuation phase for 18 months:
   p­aminosalicylic acid, Moxifloxacin, high dose lsoniazid, Clofazimine, Linezolid, Amoxicillin and Clavulinic acid.
3. Reserve drugs: Clarithromycin, Thiacetazone