Biomarkers Of Sepsis

Biomarkers Of Sepsis

Question 1. Describe differentiating features of septicemia and pyemia

Answer. Following are the differentiating features of septicemia and pyemia:

“Comprehensive Overview Of Sepsis Biomarker Types”

“What Happens If Sepsis Biomarkers Are Elevated”

Question 2. Describe differentiating features of bacteremia and septicemia.

Answer

“What Tests Measure Sepsis Biomarkers”

Question 3. Differentiate between Gram-negative and Gram-positive septicemia and management.

Answer.

“Dealing With False Positives In Sepsis Biomarkers”

Management of Gram-Positive and Gram-negative septicemia

• Correction of flid and electrolyte by crystalloids, blood transfusion. Perfusion is very/most important.
• Appropriate antibiotics—third generation cephalosporins/aminoglycosides.
• Treat the cause or focus—drainage of an abscess;laparotomy for peritonitis; resection of gangrenous bowel;wound excision.
• Pus/urine/discharge/bile/blood culture and sensitivity for antibiotics.
• Critical care, oxygen, ventilator support, dobutamine/dopamine/noradrenaline to maintain blood pressure and urine output.
• Activated C protein prevents the release of inflmmatory mediators and blocks the effcts of these mediators on cellular function.
• Monitoring the patient by pulse oximetry, cardiac status,urine output, arterial blood gas analysis.
• Short-term (one or two doses) high-dose steroid therapy to control and protect cells from effcts of endotoxemia.
  It improves cardiac, renal and lung functions.
  Single dose of methylprednisolone or dexamethasone which often may be repeated again after 4 hours is said to be effctive in Gram-negative septicemia.