Antiamoebic Drugs Question And Answers
Why It Will Be Troublesome For A Patient To Take Metronidazole If He Is In a Habit Of Taking Alcohol?
Answer:
“Role of combination therapies in managing refractory glaucoma”
Metronidazole alters the metabolism of alcohol by inhibiting the aldehyde dehydrogenase enzyme. This leads to increased blood levels of the toxic metabolite acetaldehyde.
When the blood levels of acetaldehyde increase, the patient experiences unpleasant symptoms like increased heart rate, chest pain, palpitations, dizziness, flushing, sweating, weakness, vomiting, headache, etc.
“Understanding the role of antiadrenergic drugs in treating glaucoma”
“Importance of studying antiadrenergic drugs for healthcare professionals”
Since these effects are also observed with an irreversible inhibitor of aldehyde dehydrogenase called disulfiram, this reaction is termed as a disulfiram-like reaction.
That’s why alcohol is avoided when metronidazole is induced.
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