What Is Necrosis? Types And Causes

What Is Necrosis? Types And Causes

Write A Short Note On Necrosis.
Answer:

Necrosis

Necrosis is defined as focal death along with the degradation of tissue by hydrolytic enzymes liberated by dead cells. It is invariably accompanied by an inflammatory reaction.

• Necrosis can be caused by ischemia, infection, poisoning, etc., and is invariably pathological.
• Necrosis usually precipitates an inflammatory response and is accompanied by cell swelling, lysis, and lysosomal leakage. Self-digestion of cells by enzymes liberated from their lysosomes is known as autolysis.
• Following are the events in necrosis:

Necrosis

“Role of surgical debridement in treating gangrenous necrosis”

“Understanding necrosis: Types and causes explained”

Various Cytoplasmic And Nuclear Changes In Necrosis

Necrosis Cytoplasmic Changes

• Increased eosinophilia of the cytoplasm because:
  • Loss of normal cytoplasmic basophilia caused by the loss of RNA
  • Denaturation of cytoplasmic proteins, which then bind strongly to the eosin dye.
• Presence of glassy homogenous cytoplasm due to loss of glycogen.
• There is swelling as well as vacuolation of the cytoplasm.
• Swelling of cells and organelle may eventually lead to discontinuities in cell and organelle membranes and finally rupture.
• There is the formation of myelin figures, i.e., phospholipid masses derived from damaged cell membranes.

Pathological necrosis types

“Treatment options for managing necrosis”

Necrosis Nuclear Changes

The changes in the nucleus appear in one of the following three patterns:

• Shrinkage of the nucleus and increased basophilia, i.e. pyknosis
• Nuclear fragmentation, i.e., karyorrhexis
• The nucleus undergoes dissolution, i.e. karyolysis.