Vitamin B1 Deficiency
Name important vitamins which are required for the proper functioning of nerves. Describe the sources, requirements, biochemical functions & deficiency manifestation of any one (or) Explain the role of thiamine (or) Deficiency manifestation of thiamine.
Answer:
Vitamins required for neurological functions:
- Vitamins necessary for neurological functions are
- Thiamine, Vitamin B1
- Pyridoxine, Vitamin B6
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Thiamine, vitamin B1:
Sources:
1. Plant sources
- Cereals, Pulses, oil seeds, nuts & yeast
2. Animal sources
- Pork, liver, heart, kidney, milk, etc
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Requirements:
- The daily requirement of Thiamine is
- Adults-1-1.5 mg/day
- Children- 0.7-1.2 mg/ day
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Functions:
- Thiamine pyrophosphatase, TPP, a Coenzyme of Thiamine is required in the transmission of nerve impulses.
- It is required for following enzyme activity
- Pyruvate dehydrogenase to convert pyruvate to acetyl CoA
- Alpha-ketoglutarate dehydrogenase
- Used in the TCA cycle
- Transketolase
- Utilized in hexose monophosphate shunt
- Branched-chain alpha-keto acid dehydrogenase
- Used to catalyze oxidative Decarboxylation of branched-chain amino acids
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Deficiency manifestations:
A deficiency of Thiamine results in beri beri
Symptoms:
- Loss of appetite
- Weakness
- Constipation
- Nausea
- Mental depression
- Peripheral neuropathy
- Irritability
- Numbness in the legs
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Types:
- Wet Beri Beri
- Characterized by edema of legs, face, trunk & sere us cavities
- Dry beri beri
- Associated with neurological manifestations
- Infantile Beri Beri
- Seen in infants
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