Understanding Blood Clotting Disorders

Understanding Blood Clotting Disorders

Why does blood not normally clot in the circulating blood? Give three main steps in the clotting of blood. What is the role of aspirin in blood coagulation?
Answer:

• Blood does not normally clot in the circulating blood because of the following.

“Factors influencing success with blood clotting disorder studies: Q&A”

1. 1. Smoothness of endothelial lining prevents platelets adhesion and extension of clot into blood vessel.
   2. Negatively charged particles present over endothelial lining repel the clotting factors.
   3. All the clotting factors are in inactive form.
   4. Continuous movement of blood.
   5. Presence of natural anticoagulants like heparin in the blood.
   6. Activation of fibrinolytic system.
   7. Removal of activated clotting factors from the circulation by the liver.

“Understanding blood clotting disorders through FAQs: Composition, functions, and uses explained”

• Steps in the clotting of blood:

1. 1. Formation of prothrombin activator.
   2. Conversion of prothrombin into thrombin.
   3. Conversion of fibrinogen into fibrin.

“Importance of studying blood clotting disorders for medical students: Questions explained”

• Role of aspirin in blood coagulation:
  • Thromboxane A₂ promotes platelet aggregation.
  • Aspirin irreversibly inhibits platelet cyclocygenase and thereby inhibits the synthesis of thromboxane A₂.
  • It therefore interferes with platelet aggregation and prolongs bleeding time.