Understanding Lymphadenopathy: Causes, Types, and Malignant Associations
Question. Write a short note on Thrombocytopenia.
Or
Write a short answer on thrombocytopenia.
Answer. Thrombocytopenia means decreased platelet count, i.e., less than 1,50,000 per cubic millimeter.
Etiology
Impaired platelet production:
- Due to impaired platelet production:
- Bone marrow failure:
- Aplastic anemia
- Leukemia
- Megaloblastic anemia
- Myelofirosis
- Marrow infitration.
- Selective suppression of platelet production Drugs such as sulpha drugs, rifampicin, thiazides, etc.
Understanding Lymphadenopathy: Causes, Types, and Malignant Associations
Increased consumption or destruction of platelets.
- Disseminated intravascular coagulation
- Thrombotic thrombocytopenic purpura
- Idiopathic thrombocytopenic purpura
- Gramnegative septicemia
- Viral infection.
Increased splenic sequestration.
- Hypersplenism
- Lymphoma
- Liver diseases.
Causes of Lymphadenopathy and Malignant Associations
Clinical Features
- As the count of platelets is above 1 lakh per cumm of blood, patient remain asymptomatic and bleeding time is also normal.
- As count of platelets is in between 50,000 and 1 lakh per cu mm of blood, bleeding is increased. At this stage, bleeding occur with severe trauma.
- As count of platelets reaches below 50,000, bruising is present along with purpura. At this stage, bleeding occur along with minor trauma.
- Platelet count less than 20,000 per cu mm of blood causes spontaneous bleeding.
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