Teratogenicity
“What is teratogenicity and why is it important?”
Teratogenic Drugs
It refers to the capacity of a drug to cause fetal abnormalities when administered to the pregnant mother.
- The placenta does not strictly constitute a barrier and any drug can cross it to a greater or lesser extent.
- The embryo is one of the most dynamic biological systems and in contrast to adults, drug effects are often irreversible.
“Understanding teratogenicity: Causes and effects explained”
Drugs Can Affect The Fetus In 3 Stages
- Fertilization And Implantation: Conception to 17 days failure of pregnancy which often goes unnoticed.
- Organogenesis: l8 to 55 days of gestation—the most vulnerable period, deformities are produced.
- Growth And Development: 56 days onwards-developmental and functional abnormalities can occur, for Example. ACE inhibitors can cause hypoplasia of organs, especially lungs, and kidneys; NSAIDs may induce premature closure of
ductus arteriosus.
“Common examples of teratogens and their effects”
- The type of malformation depends on the drug as well as the stage of exposure to the teratogen.
- Fetal exposure depends on the blood level and duration for which the drug remains in maternal circulation.
- The teratogenic potential of a drug is to be considered against the background of congenital abnormalities occurring spontaneously
- It is, therefore, wise to avoid all drugs during pregnancy unless compelling reasons exist for their use regardless of the assigned pregnancy category or presumed safety.
“Importance of avoiding teratogens during pregnancy”
Certain Examples Of Teratogenic Drugs
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