Side Effects Of Rifampin

Side Effects Of Rifampin

Question 1. Write Important Uses And Toxic/Side Effects Of Rifampin.
Answer:

It is an antimicrobial antitubercular drug.

Rifampin Uses

• It is the first antitubercular drug and is also used in chemoprophylaxis of tuberculosis.
• It is used in leprosy.
• Prophylaxis of meningococcal and H. influenza meningitis and carrier state.
• It is a second/third choice drug for diphtheroid and legionella infections.
• A combination of doxycycline and rifampin is used in first-line therapy of brucellosis.
• Rifampin in combination with β-lactam antibiotics is used in staphylococcal infections.

Rifampin Toxic/Side/Adverse Effects

• Hepatitis, a major adverse effect, generally occurs in patients with preexisting liver disease.
• Respiratory syndrome—breathlessness which may be associated with shock and collapse.
• Purpura, hemolysis, shock, and renal failure.
• Flu-like symptoms, i.e. fever with chills, headache, muscle and joint pain.
• Gastrointestinal disturbances, i.e. nausea, vomiting, and abdominal discomfort.
• Skin rashes, itching, and flushing.

Question 2. Classify Antitubercular Drugs. Discuss The Mechanism Of Action And Adverse Effects Of Fist Line Antitubercular Drugs.
Or
Classify Antitubercular Drugs. Mention The Mechanism Of Action And Adverse Effects Of Isoniazid (INH) And Rifampicin.
Answer:

Classification Of Antitubercular Drugs

First-line drugs: Isonazid, rifampin, pyrazinamide, ethambutol, streptomycin

Second-line drugs: Thiacetazone, para-aminosalicylic acid, ethionamide, cycloserine, kanamycin, amikacin, and capreomycin.

Newer Drugs: Ciprofloxacin, ofloxacin, clarithromycin, azithromycin, rifabutin.

Mechanism Of Action And Adverse Effects Of First-Line Antitubercular Drugs