Short Term Chemotherapy Of Tuberculosis

Question 1. Write a Short Note On Short Term Chemotherapy Of Tuberculosis.
Answer:

Short-term chemotherapy consists of short-course regimens of 6 to 9 months duration.

All regimens have two phases, i.e., initial intensive phase and continuation phase
Initial intensive phase: In this patient receives intensive treatment with 3 to 4 antitubercular drugs daily or thrice weekly for a period of 2 to 3 months. The main objective of this phase is to render the patient non-contagious.
Continuation phase: The patient receives 2 to 3 drugs, usually isoniazid and rifampicin, daily or thrice weekly for a period of 4 to 6 months. This phase eliminates persistence and prevents relapse.

Categorywise Alternative Treatment Regimens For Tuberculosis (WHO-1997)

Tuberculosis Therapy Protocol by Patient Category

Erculosis Explanation Of Standard Code

Each antitubercular drug has a standard abbreviation, i.e.
- Isoniazid (H)
- Rifampicin (R)
- Pyrazinamide (Z)
- Ethambutol (E)
- Streptomycin (S)
Numerical before a phase is the duration of that phase in months.
The number in the subscript is the number of doses of that drug per week. If there is no subscript number, then the drug is given daily.

Question 2. Classify Antitubercular Drugs.
Answer:

Classification Of Antitubercular Drugs

Antitubercular Drugs: First-Line Drugs

These drugs have high antitubercular efficacy as well as low toxicity and are used routinely.

First-line drugs are:

Antitubercular Drugs: Second-Line Drugs

These drugs have low antitubercular efficacy or high toxicity or both, and are used in special circumstances.

Second-line drugs are:

Short­ Term Chemotherapy Of Tuberculosis