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Home » Proteins Biochemistry Essay Question And Answers

Proteins Biochemistry Essay Question And Answers

July 27, 2023 by Kristensmith Taylor Leave a Comment

Proteins Biochemistry Essay Question And Answers

Name the sulfur-containing amino acids. Describe the metabolism of any one of them.
Answer:

Sulfur-containing amino acids:

  • Cysteine
  • Cystine
  • Methionine

Metabolism of methionine:

  • The metabolism of methionine is divided into three parts.

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  1. Utilization of methionine for transmethylation reaction.
  2. Conversion of methionine to cysteine and cystine.
  3. Degradation of cysteine and its conversion to specialized products.

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Proteins Biochemistry Essay Question And Answers

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1. Transmethylation reactions.

  • The transfer of methyl group from active methionine to an acceptor is known as transmethylation.
  • For this methionine need to be first activated to S-adenosylmethionine.
  • It occurs by the transfer of an adenosyl group from ATP to the sulfur atom of methionine by the methionine S- adenosyl – transferase enzyme.
  • As a result, sulfur becomes a sulfonium atom.
  • 3 ATP molecules are consumed in it.
  • Functions of S-adenosylmethionine.
    • Transfer methyl group to an acceptor from methionine.
    • Gets converted to S-adenosyl homocysteine.
  • This is hydrolyse to

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  1. Homocysteine.
    • Remethylated to methionine by N-methyl tetrahydrofolate.
    • This methionine can be reused.
  • Adenosine.
  • -S-adenosyl methionine is also involved in the synthesis of polyamines like spermine.

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2. Conversion of methionine to cysteine.

  • Homocysteine, a precursor of cysteine is initially synthesized from methionine.
  • Homocysteine then condenses with serine to form cystathionine by PLP-dependent cystathionine synthase.
  • Cleavage and deamination of cystathionine to cysteine and a-ketobutyrate occur by cystathionine synthase and cystathionine.

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3. Degradation of cysteine

  1. Cysteine and cystine are interconvertible by an NAD+ – dependent cystine reductase.
  2. Meraceptothanolamine.
    • Cysteine on decarboxylation produces it.
    • Mercaptoethanolamine is involved in the biosynthesis of coenzyme A.
  3. Cysteine sulfite.
    • Cysteine oxidizes to cysteine sulfinate by cysteine dioxygenase enzyme.
    • It cleaves alanine to sulfite. S
    • Sulfite is converted to sulfate and excreted in the urine.
  4. Cysteic acid.
    • Cysteine sulfinate oxidizes to cysteic acid.
    • This produces
      1. Taurine by decarboxylation and
      2. Pyruvate by degradation.
  5. Cysteine can be degraded by desulfhydrase to liberate sulfur, ammonia, and pyruvate.

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