Proteins Biochemistry Essay Question And Answers
Name the sulfur-containing amino acids. Describe the metabolism of any one of them.
Answer:
Sulfur-containing amino acids:
- Cysteine
- Cystine
- Methionine
Metabolism of methionine:
- The metabolism of methionine is divided into three parts.
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- Utilization of methionine for transmethylation reaction.
- Conversion of methionine to cysteine and cystine.
- Degradation of cysteine and its conversion to specialized products.
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1. Transmethylation reactions.
- The transfer of methyl group from active methionine to an acceptor is known as transmethylation.
- For this methionine need to be first activated to S-adenosylmethionine.
- It occurs by the transfer of an adenosyl group from ATP to the sulfur atom of methionine by the methionine S- adenosyl – transferase enzyme.
- As a result, sulfur becomes a sulfonium atom.
- 3 ATP molecules are consumed in it.
- Functions of S-adenosylmethionine.
- Transfer methyl group to an acceptor from methionine.
- Gets converted to S-adenosyl homocysteine.
- This is hydrolyse to
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- Homocysteine.
- Remethylated to methionine by N-methyl tetrahydrofolate.
- This methionine can be reused.
- Adenosine.
- -S-adenosyl methionine is also involved in the synthesis of polyamines like spermine.
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2. Conversion of methionine to cysteine.
- Homocysteine, a precursor of cysteine is initially synthesized from methionine.
- Homocysteine then condenses with serine to form cystathionine by PLP-dependent cystathionine synthase.
- Cleavage and deamination of cystathionine to cysteine and a-ketobutyrate occur by cystathionine synthase and cystathionine.
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3. Degradation of cysteine
- Cysteine and cystine are interconvertible by an NAD+ – dependent cystine reductase.
- Meraceptothanolamine.
- Cysteine on decarboxylation produces it.
- Mercaptoethanolamine is involved in the biosynthesis of coenzyme A.
- Cysteine sulfite.
- Cysteine oxidizes to cysteine sulfinate by cysteine dioxygenase enzyme.
- It cleaves alanine to sulfite. S
- Sulfite is converted to sulfate and excreted in the urine.
- Cysteic acid.
- Cysteine sulfinate oxidizes to cysteic acid.
- This produces
- Taurine by decarboxylation and
- Pyruvate by degradation.
- Cysteine can be degraded by desulfhydrase to liberate sulfur, ammonia, and pyruvate.
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