Pathological Features Of Syphilis

Pathological Features Of Syphilis

Question 1. Enumerate types of inflammation.
Answer:

Types of Inflammation

1. Acute Inflammation
2. Chronic Inflammation
3. Subacute Inflammation.

Question 2. Describe pathological features of syphilis.
Answer:

Pathological Features of Syphilis 

Primary Syphilis

The chancre histologically presents the following features:

• Proliferative granulation tissue is present at the margin of the ulcer.
• Dense infiltrates of plasma cells, lymphocytes and macrophages.
• Obliterative endarteritis with perivascular infiltration of chronic inflammatory cells.
• T. pallidum may be seen when immunofluorescent studies or silver staining are done.

Secondary Syphilis

• The macular lesion shows inflammatory cell infiltration and obliterative endarteritis.
• The papular lesion exhibits endothelial proliferation, swelling, and perivascular chronic inflammatory cell infiltration.
• Condyloma lata reveals hyperplastic epithelium with hyperkeratosis and acanthosis.
• Obliterative endarteritis may also be seen and there may be occasional presence of epitheloid cells.

Tertiary Syphilis

• The gumma microscopically presents a peripheral rim made up of fibroblasts, which surrounds a central zone of coagulative necrosis.
• Fibroblasts are plump and they often resemble epithelioid cells.
• The occasional presence of giant cells and the regular presence of chronic inflammatory cells like plasma cells, lymphocytes, histiocytes, etc.