Osteomalacia
Write a short note on osteomalacia.
Answer:
Osteomalacia is the adult counterpart of rickets in which mineralization of the osteoid matrix fails.
Osteomalacia Etiology
- Dietary deficiency of vitamin D.
- Poor endogenous synthesis of vitamin D.
- Conditioned deficiency.
Osteomalacia
Osteomalacia Clinical Features
- Presence of vague bony pain.
- Muscular weakness.
- Fractures following mild trauma.
- Incomplete or green-stick fractures.
- Pseudofractures in weak places of bones.
Looser’s zones in osteomalacia
Osteomalacia Histopathology
- H&E stained tissue shows widened and thickened osteoid seams.
- There is decreased mineralization between osteoid and bones.
- Increased osteoclastic activity is also appreciated.
- Fibrosis of bone marrow is present.
Osteomalacia Biochemical Changes
- Normal or low serum calcium levels.
- Low plasma phosphate levels.
- Raised alkaline phosphatase levels.
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