Oral Hairy Leukoplakia

Oral Hairy Leukoplakia

Question. Write a short note on hairy leukoplakia.
Or
Write a short answer on hairy leukoplakia.
Answer. Oral hairy leukoplakia is a condition which is present by a non-movable corrugated or hairy white lesion on the lateral margins of the tongue.

This condition occurs in 20% of patients with asymptomatic HIV infections and becomes more common as CD4+ T cell count falls.

Etiology

Epstein-Barr virus is identified in these lesions. Exact etiology is unknown.

Oral Hairy Leukoplakia Symptoms

Hairy Leukoplakia Clinical Features

• Unique and significant lesion that primarily occurs unilaterally or bilaterally on the lateral border of the tongue. It can occur on the dorsum of the tongue, buccal mucosa, floor of the mouth, retromolar area, and soft palate.
• There is of characteristic corrugated and white appearance.
• The surface is irregular and has projections, resembling hairs.
• They may spread downward onto the ventral surface of the tongue, where they appear flat.

HIV-associated oral lesions

Hairy Leukoplakia Clinical Features Management

• Acyclovir 2.5 to 3 mg per day for 2 to 3 weeks.
• Antifungal agents, i.e., cotrimazole 10 mg five times a day.
• Nystatin 10,000 units per gram 5 times a day.
• Ketoconazole 200 mg twice a day.
• Therapy of HIV by zidovudine affects Epstein-Barr virus, which leads to the regression of hairy leukoplakia.
• Topically retinoid and podophyllin resins provide temporary remission of hairy leukoplakia.