Mccune-Albright Syndrome

Mccune-Albright Syndrome

Question. Write a short note on Albright’s syndrome.
Answer. It is also known as McCune-Albright syndrome

In addition to the bone deformities, it also shows endocrine disturbances such as precocious puberty, goiter, hyperthyroidism, hyperparathyroidism, Cushing’s syndrome, and acromegaly.

McCune-Albright syndrome symptoms

• Cafe-au-lait spots are commonly seen. These are the coffees with milk color spots. An irregular flat area of increased skin pigmentation is seen.
• There is a presence of excessive vaginal bleeding.
• The main sign is the development of secondary sexual features, mainly pubic and Axillary hairs, along with the development of breasts, which occur at the age of 5 years. It can also result in crippling deformity or a fracture.
• Mainly, the long bones are the ones that are frequently affected.

McCune-Albright syndrome triad

Albright’s syndrome: Differential Diagnosis

• Peutz-Jeghers syndrome: Multiple pigmented macules are seen over the skin, which are mostly restricted to areas that encircle the body orifices.
• Addition’s disease: In adrenal insufficiency, various discrete macules are visible.