Massive Splenomegaly: Causes and Clinical Importance

Massive Splenomegaly: Causes and Clinical Importance

Question. Write a short note on massive splenomegaly.

Answer. A clinically palpable spleen is called splenomegaly, and it may be mild, moderate or massive.
When weight of spleen is over 1000 g, it is massive.

Causes

• Chronic myeloid leukemia
• Chronic malaria
• Kala­azar
• Myelofirosis
• Hairy cell leukemia
• Banti’s disease (tropical splenomegaly)
• Myeloid metaplasia
• Gaucher’s disease
• Hepatic vein obstruction.

“Understanding massive splenomegaly through FAQs: Causes and clinical importance explained”

“Importance of studying massive splenomegaly for healthcare professionals: Questions explained”

Question. Describe drug treatment of AML.

Answer. Drug treatment

Causes of Massive Splenomegaly and Diagnosis

• Induction of remission
  Daunorubicin IV alternate days 3 doses.
  Cytosine arabinoside IV BD for 10 days
• Thioguanine oral BD for 10 days.

“Common challenges in diagnosing and managing massive splenomegaly effectively: FAQs provided”

• Consolidation phase: Repeat cycle of drugs used for inducing remission, consolidation phase ranges upto 2 years.
• Cranial prophylaxis: Not required since cranial involvement only in few cases.
• Maintenance phase: Generally maintenance therapy is not required since intensive treatment in remission and consolidation phase sufficient to give relief. If relapse occurs use of ablative therapy supported by allogenic or autologous bone marrow transplantation.