Host Microbial Interaction In Periodontal Disease Question And Answers

Microbial Host Interaction With Periodontal Disease

Question 1. Write short note on prostaglandins.
Answer. Prostaglandins are arachidonic acid metabolites generated by cyclooxygenases.

• Arachidonic acid is a 20-carbon polyunsaturated fatty acid found in the plasma membrane of most cells.
• COX-2 is upregulated by IL-lb, TNF-a, and bacterial LPS and appears to be responsible for generating the prostaglandin (PGE2) that is associated with inflammation.
• The primary cells responsible for PGE2 production in the periodontium are macrophages and fibroblasts. PGE2 is increased in periodontal sites demonstrating inflammation and attachment loss.

Read And Learn More: Periodontics Question And Answers

• Induction of MMPs and osteoclastic bone resorption is induced by PGE2.
• PGE2 appears to be partly responsible for the bone loss associated with periodontitis.
• PGE2 is elevated in gingivitis and periodontitis, particularly in active disease.
• Studies in vitro demonstrated that bone loss associated with several periodontal pathogens was inhibited in part by inhibitors of prostaglandin synthesis.
• PGE2 release from monocytes of patients with severe or aggressive periodontitis is greater than that from patients with little or no periodontal destruction.