Microbial Host Interaction With Periodontal Disease
Write short note on prostaglandins.
Answer. Prostaglandins are arachidonic acid metabolites generated by cyclooxygenases.
“Understanding the role of bacteria in periodontal disease progression”
- Arachidonic acid is a 20-carbon polyunsaturated fatty acid found in the plasma membrane of most cells.
- COX-2 is upregulated by IL-lb, TNF-a, and bacterial LPS and appears to be responsible for generating the prostaglandin (PGE2) that is associated with inflammation.
- The primary cells responsible for PGE2 production in the periodontium are macrophages and fibroblasts. PGE2 is increased in periodontal sites demonstrating inflammation and attachment loss.
“Importance of studying host-microbial interactions for dental professionals”
“Common challenges in managing host-microbial interactions in periodontics”
Read And Learn More: Periodontics Question And Answers
- Induction of MMPs and osteoclastic bone resorption is induced by PGE2.
- PGE2 appears to be partly responsible for the bone loss associated with periodontitis.
- PGE2 is elevated in gingivitis and periodontitis, particularly in active disease.
“Role of diagrams and lab experiments in explaining biofilms”
- Studies in vitro demonstrated that bone loss associated with several periodontal pathogens was inhibited in part by inhibitors of prostaglandin synthesis.
- PGE2 release from monocytes of patients with severe or aggressive periodontitis is greater than that from patients with little or no periodontal destruction.
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