Hemolytic Anemia

Hemolytic Anemia

Write a short note on the classification of hemolytic anemia.
Answer:

Classification of hemolytic anemia

• Acquired or extracorpuscular.
• Hereditary or intracorpuscular.

“Role of autoimmune hemolytic anemia in immune system dysfunction”

Hemolytic anemia Acquired or Extracorpuscular

• Immunohemolytic anemia
  • Autoimmune hemolytic anemia
    1. Warm antibody autoimmune hemolytic anemia
    2. Cold antibody autoimmune hemolytic anemia

“Early warning signs of knowledge gaps in patient understanding”

• • Drug-induced immune hemolytic anemia
  • Isoimmune hemolytic anemia.
• Mechanical trauma: Microangiopathic hemolytic anemia
• Direct toxic effect: Malaria, bacteria, infection, and other agents
• Acquired red cell membrane abnormalities: Paroxysmal nocturnal hemoglobinuria.
• Splenomegaly.

“Understanding the role of hemolytic anemia in blood disorders”

Hemolytic anemia Hereditary or Intracorpuscular

• Abnormalities of red cell membrane:
  • Hereditary spherocytosis
  • Hereditary elliptocytosis
  • Hereditary stomatocytosis.
• Disorders of red cell interior:

“Importance of studying hemolytic anemia for better healthcare outcomes”

• • Red cell enzyme defect
    1. Defects in HMP shunt: G6PD deficiency
    2. Defects in the glycolytic pathway: Pyruvate kinase deficiency
  • Disorders of hemoglobin
    1. Structurally abnormal hemoglobin, sickle syndrome, and other hemoglobinopathies
    2. Reduced globin chain synthesis: Thalassemias.