Giant Cell Lesions of the Oral Cavity: Classification and Central Giant Cell Granuloma Overview

Giant Cell Lesions of the Oral Cavity: Classification and Central Giant Cell Granuloma Overview

Question. Enumerate giant cell lesions. Describe in detail the central giant cell granuloma.

Answer. Enumeration of giant cell lesions
Giant cell lesions of the oral cavity

According To The Nature Of Different Pathologic
Conditions

• Infections
  • Bacterial
  • Viral
  • Fungal
  • Protozoal
  • Parasitic
• Fibro­osseous lesions and osteodystrophies
  • Immunologic
  • Idiopathic
  • Orofacial granulomatosis
  • Reaction to materials
  • Benign and malignant tumors

“Understanding the classification of giant cell lesions in the oral cavity: Q&A explained”

In this Classification Giant Cells are Categorized into three Categories

1. Giant cells are the main cause for the pathology
2. Giant cells characterize these lesions
3. Lesions that may be associated with giant cells

Main Cause for the pathology

• Giant cell granuloma
  • Peripheral
  • Central
• Giant cell tumors
• Giant cell firoma
• Hyperparathyroidism

“Importance of studying giant cell lesions for better diagnostic outcomes: Questions explained”

Giant Cells That Characterize Lesions

• Infections
  • Tuberculosis
  • Hansen’s disease
  • Syphilis
  • Measles
• Granulomatous lesions
  • Wegener’s granulomatosis
  • Orofacial granulomatosis
  • Pulse granuloma
  • Sarcoidosis

“Common challenges in diagnosing giant cell lesions effectively: FAQs provided”

• Lesions in bone
  • Aneurysmal bone cyst
  • Cherubism
  • Paget’s disease
• Foreign body lesions
  • Silicosis
  • Berylliosis
• Malignancies
  • Lymphoma- Hodgkin’s disease
  • Bronchogenic carcinoma
  • Carcinoma of thyroid
• Miscellaneous
  • Xanthoma
  • Giant cell arteritis

“Steps to explain causes of giant cell lesions: Reactive vs neoplastic origins: Q&A guide”

Lesions that may be associated with giant Cell

• Malignancies
  • Multiple myeloma
  • Ewing’s sarcoma
  • Fibrosarcoma
  • Chondrosarcoma
• Fibro­osseous lesions
  • Osteoblastoma
  • Fibrous dysplasia
  • Cemento-ossifying firoma
  • Radicular cyst

“Role of multinucleated giant cells in central giant cell granuloma: Questions answered”

Based on their origin

• Epithelially derived, i.e. Warthin-fikeldey giant cells,tumor giant cells
• Stromally derived, i.e. Reed­sternberg giant cells.