Epithelial-Mesenchymal Interaction

Epithelial-Mesenchymal Interaction

Question 1. Epithelial-mesenchymal interaction
Answer:

• Epithelial-mesenchymal interaction governs the development of epidermal organs like teeth
• During the early stages of tooth development, a local ectodermal thickening expressing severe signaling molecules appear
• These signals to the underlying mesenchyme trigger mesenchymal condensation and tooth development

“Factors influencing success with epithelial-mesenchymal interaction studies: Q&A”

Example:

“Understanding epithelial-mesenchymal interaction through FAQs: Mechanisms, functions, and uses explained”

Genes and their action:

• Pax – 9 – determines morphogenesis
• LHX – Mesenchymal marker for initiation
• Fgf – 8 – a marker of the first branchial arch
• Bmp – 2, Bmp – 4 – patterning of tooth
• Bmp – 5 – endochondrogenesis
• Bmp – 7 – dentinogenesis
• Msx 1, Msx 2 – expresses incisor in mandible
• Msx 1, Msx 2 &Dlx – 2 – express canine
• Dlx 2 &Barx 1 – expresses molar

“Importance of studying epithelial-mesenchymal interaction for medical students: Questions explained”

Question 2. Dental lamina.
Answer:

• It results from the dividing of the primary epithelial band at around the 7th week of intrauterine life.
• It represents the lingual process of this band.
• It later breaks to form discrete epithelial islands which are named epithelial pearls.
• It serves as the primordium for the ectodermal portion of the deciduous teeth,
• It has a surface of squamous cells and a basal layer of columnar cells.

“Common challenges in mastering epithelial-mesenchymal interaction notes effectively: FAQs provided”