Enumeration Of Drugs Used In Angina Pectoris

Enumerate The Drugs Used In The Treatment Of Angina Pectoris. Discuss The Other Uses And Adverse Effects Of Nitrates.
Answer:

Enumeration Of Drugs Used In Angina Pectoris

Nitrates:
- Short-acting: Glyceryl trinitrate
- Long-acting: Isosorbide dinitrate, isosorbide mononitrate, erythritol tetranitrate, penta erythritol tetranitrate.
β Blockers: Propranolol, metoprolol, atenolol, and others
Calcium channel blockers: Verapamil, diltiazem, nifedipine, amlodipine, lacidipine.
Potassium channel opener: Nicorandil
Others: Dipyridamole, trimetazidine, ranolazine. Clinical Classification
Used to abort or terminate attack: Glyceryl trinitrate, isosorbide dinitrate.
Used for chronic prophylaxis: All other drugs.

Drugs Used in Angina Pectoris: Nitrates, Beta-blockers, and More

Other Uses of Nitrates

Myocardial Infarction: Carefully titrated IV infusion of glyceryl trinitrate to avoid tachycardia and started soon after the arterial occlusion can relieve pulmonary congestion and limit the area of necrosis by favorably altering oxygen balance in a marginally partial ischemic zone by reducing
cardiac work.
Congestive cardiac failure and acute ventricular failure: Nitrates provide relief by venous pooling of blood which decreases preload. This increases end-diastolic volume. This leads to an improvement in left ventricular function.
Interventional cardiac procedures: Nitrates are used as adjuvant drugs for dilating coronaries in percutaneous coronary angioplasty.
Biliary colic: Sublingual nitrates subsides biliary colic which is produced due to disease or morphine.
Esophageal spasm: Nitrates before a meal helps in feeding in esophageal achalasia and decreases esophageal tone.
Cyanide poisoning: Nitrates produce methemoglobin which forms cyanomethamoglobin. After this sodium thiosulphate is given to the patient which prevents dissociation and release of cyanide by forming sodium thiocyanate which is poorly dissociated and is excreted in the urine.

Angina Pectoris Treatment Drugs: Nitrates, Calcium Channel Blockers, and Beta-blockers

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