Drugs In Classical Angina

Drugs In Classical Angina

Question 1. Explain Why Nifedipine Is Referred Over Verapamil In Vasospastic Angina.
Answer:

Nifedipine is referred over verapamil in vasospastic angina because nifedipine is an arteriolar dilator so it decreases total peripheral resistance, decreasesBP, and reflex sympathetic stimulation of the heart causing increased coronary flow.

It does not depress the AV node or AV conduction and hence no decrease in venous return and cardiac work but in the case of verapamil there is depression of cardiac work and causes cardiogenic shock so that’s why nifedipine is refereed over verapamil in vasospastic angina.

Drugs in Classical Angina: Treatment Options and Mechanisms

Question 2. Discuss The Basic Use Of Propranolol In Classical Angina Pectoris.
Or
Write The Basic Use Of Propranolol In Classical Angina Pectoris.
Or
Write Basic Use Of Β Blockers In Angina Pectoris.
Answer:

Propranolol is a β-blocker.

• Propranolol causes a reduction of cardiac work and oxygen consumption by reducing total peripheral resistance due to which there is a redistribution of blood in the ischemic area.
• Propranolol reduces coronary flow without affecting the subendocardial area, which is overall effective in decreasing the frequency and severity of attacks as well as increasing exercise tolerance in classical angina.

Medications for Classical Angina: Beta-blockers, Nitrates, and Calcium Channel Blockers

Question 3. Write A Short Note On Drugs In Classical Angina.
Answer:

Angina is a discomfort resulting from acute myocardial ischemia due to coronary atherosclerosis, thromboembolism, pulmonary hypertension, and congenital abnormalities.

• The primary drug used in classical angina is nitrate or glycerine trinitrate which is sublingually administered and causes vasodilatation of the coronary artery as well as relief in pain.
• Morphine can be IV or orally administered it relieves pain as well as anxiety.
• Fibrinolytic enzymes like streptokinase or urokinase can be employed.
• Heparin can be used as an anticoagulant in classical angina.
• After the patient gets stabilized, it can be switched over to oral drugs like β-blockers or calcium channel blockers.
• Aspirin is also given as an antiplatelet drug.