Cori’s Cycle

Cori’s Cycle

Question 1. Explain Cori’s cycle.
Answer.

Cori’s Cycle

Understanding Cori’s Cycle: Lactic Acid and Glucose Metabolism

• Muscles cannot convert glucose 6 phosphate to glucose due to absence of the enzyme glucose 6 phosphatase
• Lactate formed in the muscles enters the blood and is carried to the liver where it is converted to glucose by gluconeogenesis
• The glucose thus formed then enters the muscles
• This cycle is called Cori’s cycle

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Question 2. Describe the steps of TCA cycle. Add a note on its energetics.
Answer.

Characteristic Features Of KREBS Cycle

• Krebs cycle is also known as the citric acid cycle or tricarboxylic acid cycle (TCA cycle)
• It is the final common pathway for the breakdown of carbohydrates, lipids and proteins
• It takes place in the mitochondrial matrix
• It takes place only in the presence of oxygen (aerobic conditions)
• Absence of oxygen (anoxia) or partial deficiency of oxygen (hypoxia) causes total or partial inhibition of the cycle
• NADH and FADH2 formed in the Krebs cycle enter the electron transport chain and generate ATP’s
• Intermediates of Krebs cycle play a role in the synthesis of many important compounds such as non-essential amino acids, fatty acids, haeme, cholesterol and steroids.

Cori’s Cycle: Function, Process, and Role in Metabolism

Reactions Of KREBS Cycle

• Krebs cycle takes place in the mitochondria
• Oxaloacetate combines with acetyl COA to form citrate in the first step of Krebs cycle
• Citrate then undergoes a series of reactions to regenerate oxaloacetet