Cirrhosis Of The Liver: Etiopathogenesis and Management Explained
Question. Discuss management and etiopathogenesis of cirrhosis.
Answer.
Etiopathogenesis
“Understanding cirrhosis through FAQs: Etiopathogenesis and management explained”
Hepatic cirrhosis can occur at any age and often causes prolonged morbidity.
- Any condition leading to persistent or recurrent hepatocyte death may lead to hepatic cirrhosis, e.g. viral hepatitis and alcohol, prolonged biliary damage and obstruction, as occur in primary biliary cirrhosis, sclerosing cholangitis and postsurgical biliary structures will also result in cirrhosis.
- Persistent blockages of venous return from liver, e.g. venoocclusive disease and Budd Chiari syndrome, will eventually result in liver cirrhosis.
“Importance of studying cirrhosis for healthcare professionals: Questions explained”
- Common to all cause of liver cirrhosis is activation of hepatic stellate cells.
- These cells are widely distributed throughout the liver in the space of disse.
- Following activation the fat-storing stellate cells become transformed into multifunctional cells, and cytokine synthesis.
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