Centrally Acting Sympatholytics

Centrally Acting Sympatholytics

Question 1. Explain Why Prazosin Is Used In Hypertension.
Answer:

Prazosin is a highly selective α1 blocker having α1:α2 selectivity ratio of 1000:1. All subtypes of α1 receptors, i.e. α1A, α1B, α1D are blocked equally. It blocks sympathetically mediated vasoconstriction and produces a fall in BP.

Question 2. Explain Why Ace Inhibitors Are Fist Line Drugs In The Treatment Of Hypertension.
Answer:

ACE inhibitors are first-line drugs in the treatment of hypertension because 50% of patients respond to monotherapy with ACE inhibitors and the majority of them rest to their combination with diuretics or β blockers or both.

Question 3. Explain The Mechanism Of Action And Adverse Effects Of Centrally Acting Sympatholytics.
Answer:

Centrally Acting Sympatholytics

Centrally acting sympatholytics are clonidine and methyldopa.