Causes Of Potassium Diuretics

Causes Of Potassium Diuretics

Question 1. Write The Basic Use Of Potassium Sparing Diuretics In Congestive Heart Failure.
Answer:

The potassium diuretics cause:

• Decrease preload and improve ventricular efficiency by reducing circulating volume.
  Remove peripheral edema and pulmonary congestion.
• IV furosemide promptly increases the systemic venous capacitance and produces rapid symptomatic relief.
• That’s why potassium-sparing diuretics are used in congestive heart failure.

Question 2. Write The Basic Use Of Vasodilators In CHF.
Answer:

Vasodilators are one of the important drugs used in CHF. Mainly, they are of three types based on their classification.

• Arterial dilators decrease afterload, i.e. hydralazine and nifedipine.
• Vasodilators decrease preload, i.e. glycerine trinitrate.
• Mixed dilators cause a decrease in pre- and afterload, i.e. ACE inhibitors and losartan.

They are used IV to treat acute heart failure that occurs in advanced cases and orally for long-term therapy of chronic congestive cardiac failure. They mainly act by:

• Preload reduction
• Afterload reduction
• Pre and afterload reduction.

Question 3. Explain Why Thiazide Diuretics Are Not To Be Used With Digoxin In The Treatment Of Congestive Heart Failure?
Answer:

Since thiazide diuretics promote the release of aldosterone which causes compensatory sodium retention and potassium loss leading to hypokalemia.

As digoxin leads to the inhibition of sodium-potassium ATPase and causes depletion of potassium. The thiazide diuretics enhance digitalis toxicity and cause cardiac irregularities.