Carcinoma In Situ in Oral Cavity – Signs, Symptoms, and Management

Carcinoma In Situ in Oral Cavity – Signs, Symptoms, and Management

Write a short note on carcinoma in situ.
Answer:

Carcinoma in situ

This is also called intraepithelial carcinoma.

“Early warning signs of oral carcinoma in situ explained”

• Carcinoma in situ is a condition that arises frequently on the skin but also occurs on mucus membranes including those of the oral cavity.
• Metastasis is impossible in intraepithelial carcinoma.
• Bowen’s disease is a special form of intraepithelial carcinoma occurring with some frequency on the skin, particularly in patients who have had arsenic therapy and is often associated with the development of internal or extracutaneous cancer.

Carcinoma in situ oral cavity

“Role of surgical excision in treating oral carcinoma in situ”

“Understanding carcinoma in situ: Causes and symptoms”

Carcinoma in situ Histological Features

• Keratin may or may not be found on the surface of the lesion but, if present, is more apt to be parakeratin rather than ortho-keratin.
• In some instances, there appears to be hyperplasia of the altered epithelium while in others there is atrophy.
• An increased nuclear/cytoplasmic ratio and nuclear hypo or hyperchromatism are sometimes seen.

Oral carcinoma in situ

“Global prevalence of oral carcinoma in situ”

• Cellular pleomorphism is uncommon
• There is a loss of orientation of cells and a loss of their normal polarity.
• Sometimes a sharp line of division between normal or altered epithelium extends from the surface down to the connective tissue rather than a blending of epithelial changes.