Antihypertensive Drugs

Antihypertensive Drugs

Question 1. Discuss The Mode Of Action And Advantages Of A Combination Of Atenolol With Hydrochlorothiazide As An Antihypertensive Agent.
Answer:

Atenolol Mode Of Action

Since atenolol is a β-blocker, it decreases the force of contraction, decreases AV node conduction, decreases heart rate, and decreases the automaticity of myocardial fibers; thus, cardiac work is decreased.

Hydrochlorothiazide is a diuretic, so it decreases sodium water retention, decreases body fluid, decreases venous return, and decreases cardiac work, but it is a weak antihypertensive drug.

Antihypertensive Drugs: Types, Mechanism of Action, and Side Effects

Advantages Of the Combination Of Atenolol And Hydrochlorothiazide

Hydrochlorothiazide is a weak antihypertensive and it potentiates the activity of atenolol in hypertension.

Hydrochlorothiazide has a compensatory effect on plasma renin activity because atenolol, which is a β-blocker, lowers the plasma renin activity, and diuretic, i.e,. Hydrochlorothiazide increases plasma renin activity.

Question 2. Write The Basic Use Of Potassium Channel Opener In Hypertensive Emergency.
Answer:

The potassium channel opener used in hypertensive emergencies is nicorandil.

Antihypertensive Medications: Classes and Clinical Uses

Question 3. Mention the uses and drug action of antihypertensive drugs.
Answer:

Drug Action Of Various Antihypertensive Drugs