Adverse Effects Of Isoniazid
Question 1. Discuss Isoniazid In Tuberculosis.
Or
Describe The Adverse Effects Of Isoniazid.
Answer:
Isoniazid is a fist-line antitubercular drug. It acts on extracellular as well as intracellular TB and is equally effective in alkaline and acidic medium.
Isoniazid Mechanism Of Action
Isoniazid Pharmacokinetics
Isoniazid is completely absorbed orally and penetrates all body tissues, tubercular cavities, and placenta. It is extensively metabolized in the liver by acetylation. The metabolites are excreted in the urine.
Isoniazid Adverse Reactions
- Hepatotoxicity: In chronic alcoholics, old people and rapid acetylators risk of hepatic damage is high. The effect is reversible on discontinuation of the drug.
- Peripheral neuritis: Dose-related toxicity is present. The drug promotes the excretion of pyridoxine.
- Various other side effects are fever, skin, rash, anemia, arthralgia, gastrointestinal disturbances, psychosis and rarely it causes convulsions.
Question 2. Write On Fist Line Antitubercular Drugs. Names And Their Adverse Effects.
Or
Enumerate First Line Antitubercular Drugs And A Characteristic Adverse Drug Reaction Seen With Each Of Them.
Answer:
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