ACE Inhibitors: Mechanism, Uses, and Side Effects

ACE Inhibitors: Mechanism, Uses, and Side Effects

Question. Write short note on ACE inhibitors.

Answer. The ACE inhibitors are Captopril, Enalapril and Ramipril.

Mechanism of action

• These drugs prevent conversion of angiotensin I into angiotensin II by inhibiting angiotensin­converting enzyme thus preventing action of angiotensin II, i.e. vasoconstriction and aldosterone synthesis and causes fall in BP
• ACE metabolizes bradykinin which is a potent vasodilator.
• ACE inhibitors increase bradykinin levels causing vasodilatation.

“Understanding ACE inhibitors through FAQs: Mechanism, uses, and side effects explained”

Pharmacological actions

• ACE inhibitors decrease total peripheral resistance, and hence there is decrease in systolic and diastolic blood pressure.
• ACE inhibitors increase blood supply to renal, cerebral and coronary arteries.
• ACE inhibitors causes decrease in aldosterone synthesis,and hence there is decrease in sodium and water retention.

“Common challenges in managing ACE inhibitor therapy effectively: FAQs provided”

Adverse Effects

ACE inhibitors produce hypotension, hyperkalemia, dry persistent cough, loss of taste sensation, urticaria, angiedema,etc.

“Importance of studying ACE inhibitors for healthcare professionals: Questions explained”

Uses

• Hypertension: ACE inhibitors are fist line drugs to be used in the treatment of hypertension. They are used alone or in combination with other drugs. These drugs are more effctive in renovascular hypertension.
• Congestive heart failure: ACE inhibitors decreases preload and afterload in CHF.
• Diabetics: In diabetics, renal functions are improved.
• Myocardial infarction: In myocardial infarction motility is reduced.