Aspirin (Acetylsalicylic Acid): Pharmacology, Indications, and Side Effects

Aspirin (Acetylsalicylic Acid): Pharmacology, Indications, and Side Effects

Question. Write short note on aspirin.

Answer.

Aspirin:

Chemical name of aspirin is acetyl salicylic acid.

Pharmacological action

• It decreases the temperature by bringing temperature regulating centre to normal when it becomes deranged.
• Aspirin block pain centre in thalamus. It also inhibits synthesis of prostaglandins and prevent sensation of pain receptors to histamine, bradykinin and 5 hydroxy tryptamine, mediators of pain and inflmmation.
• Aspirin inhibits platelet aggregation by inhibiting ADP release from platelets and inhibiting the synthesis of prostaglandin, endoperoxidase and thromboxane A2.

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Indications

• It acts as keratolytic, fungistatic and mild antiseptic.
• As analgesic, antipyretic and antirheumatic.
• It prevents platelet aggregation.

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Side Effects

• Nausea and vomiting
• Increases prothrombin time.
• Fatt infitration of liver and kidney.
• Salicylism: Headache, dizziness, vertigo, tinnitus,
  diminished hearing and vision.
• It causes respiratory depression.