Pyrazinamide in Tuberculosis Treatment: Uses, Action, and Side Effects

Pyrazinamide in Tuberculosis Treatment: Uses, Action, and Side Effects

Question. Describe briefly pyrazinamide.

Answer.

Pyrazinamide

It is an antitubercular drug.

It inhibits mycolic acid synthesis.

• Pyrazinamide is absorbed orally and has good penetration in CSF.
• Hepatotoxicity is more important dose-dependent adverse effct.
• It is contraindicated in patient with the liver disease.
• Other adverse effcts are arthralgia, flshing, rashes,fever, etc.

“Understanding pyrazinamide through FAQs: Uses, mechanism of action, and side effects explained”

Question. Describe briefly the side effects of corticosteroids.

Answer.

Side Effects

• In hyperglycemia, they cause precipitation of diabetes and glucosuria.
• They cause muscular weakness.
• They cause thinning of skin, fragile skin and purple striae hirsutism.
• They cause Cushing’s habitus in which there is moon face, narrow mouth and obesity of trunk with thinning of lungs.
• They increase susceptibility to infection, i.e. TB and opportunistic infection may flre up.

“Importance of studying pyrazinamide for healthcare professionals: Questions explained”

• They cause delayed healing of wound and surgical incisions.
• They causes peptic ulcer.
• They causes osteoporosis, glaucoma and growth retardation in children.
• At high doses, they causes psychiatric disturbance.
• They cause suppression of the hypothalamic-pituitary axis.