RNTCP Classification of Tuberculosis: Drugs, Doses, and Regimens Explained

RNTCP Classification of Tuberculosis: Drugs, Doses, and Regimens Explained

Question. Write on the RNTCP classification of tuberculosis.

Answer. RNTCP or the Revised National Tuberculosis Control Program is the state­run tuberculosis control initiative of the Government of India. It incorporates the principles of directly observed treatment­short course (DOTS), the global TB control strategy of the World Health Organization.

The program provides, free of cost, quality anti­tubercular drugs across the country through the numerous Primary Health Centres and the growing number of private­sector DOTS­providers.

Objectives of pulmonary embolism.

1. Detecting at least 70% of sputum-positive tuberculosis patients in the community.
2. Curing at least 85% of the newly detected sputum-positive cases.

RNTCP classifies tuberculosis patients into the following treatment categories.

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Explanation of standard code pulmonary embolism.

1. Each antitubercular drug has standard abbreviation, i.e.

1. Isoniazid (H)
2. Rifampicin (R)
3. Pyrazinamide (Z)
4. Ethambutol (E)
5. Streptomycin (S)
6. H: Isoniazid (300 mg), R: Rifampicin (450 mg),Z: Pyrazinamide (1500 mg), E: Ethambutol (1200 mg),S: Streptomycin (750 mg).

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2. Patients who weigh 60 kg or more receive additional Rifampicin 150 mg.

3. Patients who are more than 50 years old receive
Streptomycin 500 mg. Patients who weigh less than 30 kg
receive drugs as per pediatric weight band boxes according to body weight.

4. Numerical before a phase is the duration of that phase in months.

5. Numerical in subscript is the number of doses of that drug per week. If there is no subscript numerical, then the drug is given daily.

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Treatment regimen under rntcP for Mdr-tB (Multidrugresistant tB) and Xdr—tB (extensively drug resistant tB)

1. For MDR-TB:

1. Six drugs in intensive phase for 6–9 months: Kanamycin,Levoflxacin, Ethionamide, Cycloserine, Pyrazinamide and Ethambutol.
2. Four drugs in continuation phase for 18 months:
   Levofloxacin, Ethionamide, Cycloserine and Ethambutol.
3. Reserve drug is p­aminosalicylic acid.

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2. For XDR—TB:

1. Seven drugs in intensive phase for 6-12 months:Capreomycin, p-aminosalicylic acid, Moxiflxacin,high dose Isoniazid, Clofazimine, Linezolid,Amoxicillin and Clavulinic acid.
2. Six drugs in continuation phase for 18 months: p­aminosalicylic acid, Moxifloxacin, high dose lsoniazid, Clofazimine, Linezolid, Amoxicillin and Clavulinic acid.
3. Reserve drugs: Clarithromycin, Thiacetazone

Second-line antituberculous drugs

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