Antithrombolytics
Question 1. Explain Why Heparin Is Used As An Anticoagulant.
Answer:
Heparin acts indirectly by activating plasma antithrombin III. The heparin-AT III complex then binds to clotting factors of the intrinsic and common pathways (Xa, IIa, IXa, XIa, XIIa, and XIIIa) and inactivates them but not factor VIIa operative in the extrinsic pathway.
At low concentrations of heparin, factor Xa-mediated conversion of prothrombin to thrombin is selectively affected.
The anticoagulant action is exerted mainly by inhibition of factor Xa as well as thrombin (IIa) mediated conversion of fibrinogen to firin’.
Question 2. Write Short Note On Antithrombolytics In Clinical Dentistry.
Answer:
Antithrombolytics are also known as antifibrinolytics.
These are the drugs that inhibit plasminogen activation and dissolution of clots.
Drugs used are epsilon amino caproic acid and tranexamic acid.
In clinical dentistry, they are used after tooth extraction in hemophilics.
They are also useful in reducing bleeding after tooth extraction or after dis impaction of the tooth.
In dentistry, tranexamic acid-soaked gauze or mouthwash is used to stop postoperative bleeding in hemophiliacs as well as in patients on anticoagulant therapy.
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