Liver Function Tests: Key Parameters and Their Clinical Significance

Liver Function Tests: Key Parameters and Their Clinical Significance

Question. Write short note on liver function test.

Answer.

Liver Function test

“Factors influencing success with liver function test knowledge: Q&A”

Serum Bilirubin

• The normal level is 1 mg / 100 mL.
• It increases in:
• Hepatocellular injury
• Posthepatic biliary obstruction.

Thymol turbidity test

• Demonstrating hepatic cellular dysfunction
• Gamma globulins are mainly responsible for positivity in this test.

“Understanding liver function tests through FAQs: Key parameters and clinical significance explained”

Enzyme in liver disease

1. Alkaline phosphate:

• Elevation occurs in obstructive jaundice.
• Mild elevation in xanthomatous cirrhosis, hepatocellular injury, liver abscess.

2. SGOT (serum glutamine oxalate transferase):

• Normal level is 5 to 40 unit
• It increases in all conditions leading to hepatic necrosis and in alcoholic liver damage.

“Common challenges in interpreting liver function tests effectively: FAQs provided”

3. SGPT (serum glutamine pyruvic transferase)

• It is more specifi for liver disease.
• It is raised in sever parenchymal damage to liver.
• For example, chronic acute hepatitis, alcoholic liver disease, biliary obstruction.

“Importance of studying liver function tests for healthcare professionals: Questions explained”

4. GGT (gamma glutamyl transpeptidase): Sensitivity test for alcoholic liver disease and for hepatobiliary disease.

5. Leucine amylo peptidase: It increases in primary liver diseases.

6. Serum pseudocholinesterase:

• It has limited value.
• Value decreases in sub­acute and chronic parenchymal diseases of liver (Cirrhosis).