Glyceryl Trinitrate

Glyceryl Trinitrate

Question 1. Write A Short Note On Glyceryl Trinitrate.
Answer:

Glyceryl trinitrate is an anti-anginal drug.

• It is a volatile liquid that is adsorbed on the inert matrix of the tablet and rendered nonexplosive.
• The sublingual route is used when terminating an attack or aborting an imminent one is the aim.
• The tablet may be crushed under the teeth and spread over the buccal mucosa.
• It acts within 1–2 min because of direct absorption into the systemic circulation.
• Plasma t1/2 is 2 min, the duration of action depends on the period it remains available for absorption from buccal mucosa. The remaining part of the tablet may be spit or swallowed when no longer needed.
• A sublingual spray formulation has been recently introduced which acts more rapidly than the sublingual tablet.
• Hepatic metabolizing capacity can be overwhelmed by administering a large dose (5–15 mg) orally.
• Sustained-release oral capsules containing much larger amounts of glyceryl trinitrate can be used for chronic prophylaxis.

Glyceryl Trinitrate: Uses, Mechanism of Action, and Dosage

Question 2. Explain The Drug Interaction Between Nitrates And Β Blockers.
Or
Write In Briefdruginteraction Ofnitrates And Β Blockers.
Answer:

Nitrates improve blood flow by relaxing and dilating (expanding) veins and arteries, including the coronary arteries.

They reduce the amount of blood returning to the heart while Beta-blockers reduce the heart rate, blood pressure, and the force of the heart’s contractions, thereby decreasing the amount of oxygen the heart requires to pump blood.

Along with nitrates, beta blockers are usually the first choice for the treatment of stable angina, and are particularly beneficial in people who have angina during exercise or activity.

Glyceryl Trinitrate for Angina: Treatment and Efficacy

Another important benefit of beta blockers is that they improve survival and prevent another heart attack in people who have suffered a recent heart attack.